Comparison of Modern In Vitro Permeability Methods with the Aim of Investigation Nasal Dosage Forms

Nowadays, the intranasal route has become a reliable alternative for drug administration to systemic circulation or central nervous system. However, there are no official in vitro diffusion and dissolution tests especially investigation of nasal formulations. Our main goal was study compare well-known lesser-known permeability method, order ascertain which suitable determination through mucosa from different The vertical cell (Franz cell) compared with horizontal model (Side-Bi-Side). Raw nanonized meloxicam containing dosage forms (spray, gel powder) were tested compared. It found that Side-Bi-Side spray powder forms. In contrast, not measurable on cell; due its high viscosity, uniform distribution active substance could be ensured donor phase. Franz cell, designed analysis semi-solid formulations, desirable gels. can concluded application is recommended liquid solid preparations, while one should used